Carrier-based formulations are commonly used in drug delivery systems, particularly in inhalation therapies. These formulations involve dispersing active pharmaceutical ingredients (APIs) onto carrier particles, facilitating their delivery to the lungs.
In this webinar you can find more information about the requirements for pulmonary delivery via carrier-based inhaled powder formulations, and how jet milling can be used to manufacture effective and stable materials for these formulations.
In the current paper, we summarize the key considerations in carrier-based formulations as being:
- Carrier Selection:The choice of carrier material is crucial, as it influences factors like particle size distribution, surface properties, and aerosol performance.
- Formulation Process:The process of combining the API with the carrier involves techniques like jet milling, spray drying, and fluid bed processing. Optimization of these processes is essential for achieving desired particle size and distribution.
- Process Optimization: Factors like temperature, humidity, and processing time can significantly impact the final product. Careful control of these parameters is necessary to ensure consistent quality.
- Characterization:Characterization techniques, such as particle size analysis, surface area measurement, and powder flow properties, are used to assess the quality of the formulation.
Read the paper to learn more.