Stability of Powder-Filled Hard Gelatin Capsules Stored in Standard I.C.H. Conditions

The work presented hereafter illustrates that the selection of the blister type is crucial to document the stability of product filled in hard gelatin capsules when tested under the standard I.C.H. conditions. The purpose of this study is to determine the design space for gelatin hard capsules filled with acetaminophen tablets in blisters of variable porosity and stored under I.C.H. storage conditions.