Efficiently develop and manufacture SDDs and dosage forms
Drug product intermediates based on SDD technology can be formulated into capsules, tablets and other solid dosage forms.
With our integrated approach to product development, you’ll get efficient manufacturing for all stages of development and commercial-scale production:
- Proprietary mini spray-drying equipment designed for feasibility assessments and prototype development based on the minute quantity of API (as low as 100 mg)
- Non-GMP development facility to support rapid product development
- Small-to-mid-sized spray dryers for scale-up, QBD studies and production of toxicology study supplies
- Commercial-scale spray dryers in a non-GMP environment for seamless process development and commercial scale-up to GMP.
- GMP production capabilities for the manufacture of registration lots, commercial launch quantities and ongoing supply of SDD intermediate
Pharmaceutical spray-dried dispersion applications
Many of today’s drug candidates have low aqueous solubility (BCS II) and need an enabling technology to enhance oral bioavailability.
Amorphous solid dispersion using spray-dried dispersion technology is the perfect solution. This significantly improves the bioavailability of promising BCS ll compounds, so you can ensure more of the drug is absorbed in the bloodstream and, as a result, bring more products to market.
Dry powder inhaler (DPI)
Spray drying is also increasingly used for dry powder inhaler (DPI) applications, as it provides spray-dried particle engineered formulations with the required size distribution to meet target product profiles.
Respiratory product development platform
- Spray dried particles
- Particle engineering using particle size reduction/ spray drying
- Phase appropriate encapsulation
3-step SDD process to improving bioavailability
SDD technology significantly improves bioavailability - typically from 3 to 5-fold.
Design
The first step is understanding your problem statement and clearly defining the target product profile (TPP).
Develop
Starting from the design and TPP, a team of experienced scientists and engineers develop the product using a proven roadmap approach. Generally, the formulations developed are “phase appropriate” to match the current development phase of the drug candidate.
Manufacture
We have a full range of pharmaceutical spray dryers, based on proprietary designs, to support early feasibility assessments through clinic studies and commercialization.
Lonza Bend: from preclinical to late-stage development to commercialization
Inhaled Drug Product Expert for Large and Small Molecule