UC-II® undenatured type II collagen is the next generation joint health ingredient, clinically studied to help reduce joint discomfort and improve flexibility and mobility in healthy, active adults1-3.

Unlike hydrolyzed collagen which requires a large daily dose (up to 20,000 mg a day) and glucosamine and chondroitin, UC-II® undenatured type II collagen supports joint health with just one small 40 mg dose per day1-5.

Fuel the new era of active lifestyle consumers with a different form of collagen

Clinically-proven benefits

The most researched brand of undenatured type II collagen*

Low dose

Unsurpassed consumer convenience with just one small 40 mg daily dose2-5

Unique mechanism of action

Triggers the immune system to build joint cartilage6-8

Formulation innovation

Works across a wide range of in-demand dosage forms9

*as of January 2024

UC-II® undenatured type II collagen triggers the immune system to build joint cartilage

Undenatured type II collagen's structure is uniquely preserved in the UC-II® ingredient using a patented, low-temperature processing method.

Epitopes are the bioactive regions that allow undenatured type II collagen to bind to the Peyer's patches in the gut and induce the oral tolerance process.

The three dimensional shape of undenatured type II collagen preserves the bioactive regions called epitopes that induce the oral tolerance process.

Undenatured type II collagen is resistant to gastric acid and digestive enzymes, allowing it to retain the three dimensional shape and to preserve the epitopes.


UC-II® undenatured type II collagen makes daily pill compliance and repeat-purchase easy

Compared to other joint health ingredients, UC-II® undenatured type II collagen's small 40 mg dose makes daily pill compliance easy.

8 out of 10 consumers

say easy-to-swallow is important when making supplement purchasing decisions7

Joint health ingredient dosing
UC-II undenatured type II collagen small pill
Hydrolyzed collagen large scoops
Curcumin large capsules
MSM large capsules
Glucosamine and chondroitin very large tablets

In the Media


Latest news
  1. Schön et al. (2022). J Integr Complement Med, 28(6), 440-548.
  2. Lugo et al. (2013). J Int Soc Sports Nutr, 10(1), 48.
  3. Lugo et al. (2016). Nutr J, 15(14)
  4. Knaub et al. (2022). J Clin Trials, 12(1):1000492.
  5. Bagi CM, Berryman ER, Teo S, Lane NE. (2017).
  6. Osteoarthritis Cartilage, 25(12), 2080-2090.
  7. Yaremenko et al. (2021). PAIN, JOINTS, SPINE, 11(3), 5-92.
  8. Sahin et al. (2023). Scientific reports, 13(1), 6499.
  9. Pates, et al. (2023) g. Data in Brief, 48, 109216