Impact of Process Re-design on Sustainability in Pharmaceutical Small Molecule Manufacturing

A recent study revealed, that the pharmaceutical industry is significantly more emission-intensive than the automotive industry¹. In a cradle-to-grave perspective, the impact of supply chain on the carbon footprint of pharmaceutical companies operations by far exceeds the impacts related to waste production and treatment^{2, 3}.

Therefore, it is of highest priority that pharmaceutical manufacturing becomes more efficient regarding the use of resources.

In this webinar, we:

• Extensively describe the optimization of the manufacturing process of a pharmaceutical intermediate
• Demonstrate that yield can be improved substantially via suitable reaction engineering
• Show that the implemented optimizations come along with a net increase in quality of the obtained intermediate

1. L. Belkhir, A. Elmeligi, Journal of Cleaner Production, 2019, 214, 185-194.
2. C. Jimenez-Gonzalez, C. S. Ponder, Q. B. Broxterman, J. B. Manley, Org. Process Res. Dev. 2011, 15, 4, 912–917.
3. Lonza Sustainability Report 2021, 2022, 35 ff.