Modeling Phase Separation Risk During Spray Drying from Mixed Solvents

Low organic solubility compounds in need of bioavailability enhancement by spray drying are increasingly prevalent in many development pipelines. Using mixed aqueous/organic solvents is one way to improve organic solubility, thereby increasing process throughput, though this approach may impart phase separation risks by solvent enrichment during drying. Practical tools for predicting the impacts of mixed solvents on the properties and performance of spray-dried dispersions is an important gap in process and formulation development. This work presents a model for droplet drying and phase behavior in a four-component system, incorporating two different solvents. To learn more, download our rapid fire presentation.