Downstream BPI Automation of a Protein Solubility and Stability Screen

Chimeric constructs constituting complex products often have compromised solubility and stability characteristics. An automated workflow has been developed to rapidly identify process conditions and product concentrations complex products can be manufactured at. As a result protein solubility data can be generated in a broad range of buffer and excipient compositions using low amounts of material. The data can be  leveraged to inform chromatographic purification study design.