Lonza's GS Gene Expression System® is widely used for the expression and manufacturing of biologics. The latest addition to the GS® toolbox, GS Effex® is a FUT8 knockout cell line derived from the industry-known GS Xceed® CHOK1SV GS-KO®. GS Effex® produces antibodies free of fucose.
This lack of fucose enhances antibody-dependent cellular cytotoxicity (ADCC), increasing the potency of antibody immunotherapies.