Proven High Titers with GS piggyBac®

GS piggyBac® is a unique and versatile cell line engineering technology. Benefit from access to a proven transposon-based technology that preferentially targets stable regions of the genome associated with highly expressed genes.

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>35 Years' Experience

We have extensive experience in developing and delivering with market leading protein expression platforms.

Scalable and Regulatory-compliant Processes

We can help you develop robust, efficient, scalable and regulatory-compliant processes to equip you for ultimate commercial success.

>75 Molecules

In clinic manufactured with our expression platforms.

GS piggyBac®

The GS piggyBac® system uses an engineered hyperactive piggyBac™ transposase enzyme to insert GS Xceed® expression vector cargos with your gene of interest into the host cell genome with high efficiency with the following benefits:

Enhanced performance of GS piggyBac® is observed with low versus high expressing monoclonal antibodies
Accommodating a large DNA cargo (> 200kb) makes GS piggyBac® highly suited to support cell line engineering needed to enhance complex protein expression
Preferentially targeting genetically stable parts of the genome at high efficiency has the potential to improve cell line stability

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Express vector cargos into the host cell genome with high efficiency

Combining our GS System® with piggyBac® Transposon Technology can result in increased yields versus GS System® alone. Available to new and existing GS System® license holders.

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From our clients

25 April 2022 - Luzhu Biotech Develops Recombinant Herpes Zoster Vaccine and Bispecific Antibody using Lonza’s GS Xceed® Gene Expression System

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Expression Technical Support

Technical support for your development journey, based on over 35 years of expertise in protein expression and 20 years with viral gene manufacturing.

Our locations

Our R&D Centers of Excellence

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Cambridge, United Kingdom

Cambridge, United Kingdom

Visp in the Fall

Visp, Switzerland

Slough exterior

Slough, United Kingdom

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Services enabled by this technology

Rapid Host Screen and Early Protein Expression

Select the optimal expression system for your biotherapeutic protein production with our Rapid Host Screen service and express milligram to low gram...

Non-GMP Manufacture: Light Path™ Discovery

Our Light Path™ Discovery Protein Production Services provide milligram to low gram quantities of non-GMP product for manufacturability, safety and...

Mammalian Cell Line Development

Benefit from our flexible approach to cell line development matching your project’s priorities in terms of timelines, yield optimization and risk....

Biologics

Related Insights

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Bispecific Antibody Development: Upstream Challenges and Strategies

Biological pipelines are evolving from standard antibody formats to next-generation biologics such as bispecific antibodies (bsAbs). However, these...

Technical/Service brief

GS Xceed® Gene Expression System Brochure

GS Xceed® is a scalable, integrated, proven platform for developing biotherapeutics. The system is supported by Lonza’s extensive experience and...

Webinar on-demand

Webinar (on-demand)

Right First Time: Successfully Progressing Biotherapeutics from Discovery to the Clinic

It is essential that the best approaches and tools are selected to maximize success when moving a selected candidate through development. In this...

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Tools for Developing Successful Biologics - Vectors for the GS Gene Expression System®

We have developed a series of advanced vector systems with applications in producing standard monoclonal antibodies, antibody-drug conjugates as well...

Becoming a Champion Go Player

Although antibodies, at the time of writing, still dominate the clinic, there is a definite shift in the drug development pipeline towards more...

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