For more than 125 years, our business has consistently embraced change in order to remain relevant to our customers and the world around us. Here, we explore some of the current developments within our industry and the wider world. By remaining agile in a rapidly evolving world, we continue to lead the way as a pioneer and leader in the CDMO industry.
A Changing World
Population Growth and Globalization
There is a confluence of change as the world’s population continues to grow and experience higher levels of global mobility. This can deliver many benefits, from improved life quality to accelerated economic development. However, it can also contribute to serious health challenges, as seen in the speed and scale at which the Covid-19 pandemic spread across markets and regions. These heightened levels of vulnerability to population-level infections must be met with a greater focus on the speed of commercialization and the scale of manufacturing, both of which are priorities for our business.
Aging World Population
As life expectancy continues to increase in many markets, there is an ongoing focus on the growing prevalence of diseases that may be related to age, including cancer, heart disease, diabetes and many other illnesses. Across our business, we are playing an active role in addressing the increasing global need for medicines by turning our customers’ breakthrough innovations into viable therapies and making the medicines that will help to address age-related health conditions.
Technological Advances
In recent years, digital advances have driven a new era of innovation. This global trend has wide-reaching implications for many industries including medicine, life sciences and healthcare manufacturing.
Digitalization brings opportunities to integrate innovative technologies into the drug development and manufacturing journey. We are pioneering digitally connected processes that support improved speed, flexibility and efficiency, while managing cost and maintaining value. Such integrated technologies can unlock greater depth of knowledge, supported by advanced data insight, to optimize and control processes.
We are actively adopting technology and automation at Lonza to streamline operations, decrease manual involvement and improve data-driven decision making. This includes implementing virtual reality (VR) training, robotics, real-time data analytics and advanced modeling tools.
Sustainability: An Ethical and Operational Imperative
People, businesses and governments worldwide have become increasingly aware of the urgent need to address environmental issues and promote ethical practices. The corporate community has a critical role to play in securing a sustainable future.
Across our global network, we are committed to improving our social engagement and governance while reducing our environmental footprint. Our ambitious sustainability targets will deliver efficiency back to our business and stakeholders, while delivering long-term value environmentally, economically and socially.
A Changing Industry
Innovation in Discovery, Development and Manufacturing
We see that large pharma companies are placing increased focus on drug discovery and development. At the same time, small biotech companies continue to drive innovation in discovery across both developing and emerging markets.
To support this focus on early-stage innovation, CDMO partnerships are becoming an integrated part of the healthcare business model. Manufacturing innovation by CDMOs provides critical tools to support the future success of novel drug candidates. By boosting manufacturing efficiency and effectiveness, we can enable developers to focus on novel and complex treatments to target unmet medical needs.
From “blockbusters” to “nichebusters”
There is an expanding focus in the pharmaceutical industry from classic “blockbuster” drugs – targeting widespread conditions with a large patient population – to also include the development of niche medicines designed to treat rare and orphan conditions. Advancements in genomics, proteomics, personalized medicine and technology, alongside a more sophisticated understanding of rare conditions, are helping to unlock new therapeutic possibilities.
Such journeys face challenges ranging from higher failure rates and development costs, to regulatory and manufacturing hurdles. Developers can benefit from partnering with experienced CDMOs to help de-risk this journey and realize the commercial potential of their novel therapies.
The Rise of Complex Therapies
As treatments are becoming increasingly complex, the path to commercialization is becoming more challenging to navigate. The emergence of advanced modalities and technologies brings complicated manufacturing challenges. Advancing complexity can be observed in services relating to highly potent active pharmaceutical ingredients (HPAPIs), bioconjugates, bispecific antibodies, cell and gene therapies and mRNA.
This complexity in the clinical pipeline is driving demand for experienced CDMOs that can help drug developers to de-risk their investments and accelerate time to market. In a fast-changing environment, Lonza’s ability to support customers across the entire product lifecycle has never been more important.
Growing Demand for Integrated CDMO Services
CDMOs now play a critical role in the value chain for large pharma, emerging start-ups and everything in between. The trend for outsourcing continues – driven by strong and sustained commercial demand and a healthy drug development pipeline.
By offering a range of flexible business models, and access to deep scientific, manufacturing and regulatory expertise, we can help drug developers of all sizes to bring their innovative therapies to life. Our breadth of offerings and technologies means we are well positioned to meet changing customer requirements while securing our own long-term growth and success.