Cell & Gene Technologies
Our value proposition is predicated on quality, expertise and trust. Over the last twenty years, we have established a leading position based on our process development and GMP manufacturing experience. With a robust position in key modalities, from process development to commercial manufacturing, our offering is one of the most complete in a highly fragmented industry.
Cell and gene processes are predominantly smaller-scale and still highly manual. As a result of leveraging our strong manufacturing expertise and reputation to deliver highly complex therapies, we have gained and also retained a large proportion of outsourced, late-stage clinical and commercial cell and gene products in the CDMO industry. As of 2023, Lonza manufactured three of the 12 outsourced commercial cell and gene therapy products approved in Europe and the United States.
Bioscience
Our Bioscience business unit has a strong portfolio of products and services that support the growth of the biologics and cell and gene markets. Our customers rely on our offering to deliver improved reliability, reduced variability, ease of use, high performance and cost efficiency. Our Bioscience products and services range from cell culture and discovery technologies for research, to quality control tests and software for biomanufacturing.
For example, Endotoxin testing is a critical test required to ensure the safe release and use of every parenteral product delivered intravenously to a patient. In 2023, we launched a new microplate reader, the Nebula® Absorbance Reader, as part of our Endotoxin and pyrogen testing portfolio to support QC labs. The updated reader provides improvements in accuracy, consistency and greater flexibility for use.
Personalized Medicines
The cell therapy production process is extremely complex. It can take four to six weeks between collecting the cells and infusing the treatment back to the patient. Furthermore, current solutions are not sufficiently scalable to meet patient demand.
Our Cocoon® Platform is a functionally closed, highly flexible and scalable autologous cell manufacturing solution, addressing many of these challenges.
- It provides point-of-care treatment, which can mitigate delays, shipping complexity and related costs.
- It is highly automated, which reduces both the costs associated with manual intervention and the risks associated with human error.
- It is scalable, as multiple instruments may be connected in the future, which has the capacity to save significant clean room space.
To date, we have installed more than 100 Cocoon devices and currently work with more than 20 customers. Through our large-scale, point-of-care manufacturing partnership with Galapagos, we have been able to consistently deliver treatments with vein-to-vein turnaround times in as little as seven days.
